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The primary mode of action for most alkylating drugs is via cross-linking of DNA strands. Alkylating agents (ATC code L01A) are highly reactive compounds that easily attach to DNA and cellular proteins. The primary mode of action for most alkylating drugs is via cross-linking of DNA strands. From Wikipedia, the free encyclopedia An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (C n H 2n+1) to DNA. The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the purine ring. Alkylating agent, any highly reactive drug that binds to certain chemical groups (phosphate, amino, sulfhydryl, hydroxyl, and imidazole groups) commonly found in nucleic acids and other macromolecules, bringing about changes in the DNA and RNA of cells. Alkylating agents are a class of antineoplastic or anticancer drugs which act by inhibiting the transcription of DNA into RNA and thereby stopping the protein synthesis.
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Alkylating agents Temobel capsules 20 mg, 100 mg, 250 mg Trade name: Temobel. International nonproprietary name: Temozolomide. Pharmaceutical form: capsules 20 mg, 100 mg and 250 mg. Composition: each capsule contains: Active ingredients: temozolomide. Excipients: stearic acid, tartaric acid, colloidal anhydrous 2020-12-05 · Alkylating agents have been used for the treatment of cancer for over six decades, yet their repertoire continues to grow.
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Highly electrophilic compounds that react with nucleophilic groups on DNA to form strong covalent bonds. Can cause interstrand or intrastrand •Alkylating agents: cyclophosphamide (dose of 2 mg/kg per day for 8 to 12 weeks (maximum cumulative dose of 168 mg/kg).
Antineoplastic agents that include in their structure highly reactive chemical moieties comprise the earliest class of drugs for treating malignant tumors.
react with electron rich atoms in DNA bases to form covalent bonds (alkylation); nucleophilic substitution -chorine atom is
Introduction and Therapeutic Uses.
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Alkylating agents (al-ka-LAYT-ing AY-jints) are a family of anticancer drugs that interfere with cell's DNA and inhibit Alkylating Agents: In Vitro Studies of Cross-Resistance Patterns in Human exposing cells to escalating doses of an alkylating agent, we have devel oped four Alkylating agents represent an important class of anticancer drugs. The occurrence and emergence of tumor resistance to the treatment with alkylating agents Alkylating anticancer drugs are effective during all phases of cell cycle and are used to treat a wide variety of cancers.
Alkylating agents form highly reactive intermediate compounds that are able to transfer alkyl groups to DNA. Alkylation can result in miscoding of DNA strands, incomplete repair of alkylated segments (which leads to strand breakage or depurination), excessive cross-linking of DNA, and inhibition of strand separation at mitosis. Alkylating agents • Alkylating agents produce highly reactive carbonium ion intermediates or related transition complex which transfer alkyl group to cellular macromolecules by covalent bonds. • Alkylating agents cross link with carboxyl, hydroxyl, amino, sulfhydryl and phosphate groups of biomacromolecules results abnormal base paring/ scission of DNA Stand.
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